The clinical effectiveness of trastuzumab for breast cancer: a systematic review.
نویسندگان
چکیده
Searching MEDLINE, EMBASE, Cancerlit, BIOSIS Previews, the Index to Scientific and Technical Proceedings, the Cochrane Controlled Trials Register, DARE, NHS EED and the National Research Register were searched to August 2001; the search terms and strategies were reported in depth. The authors identified additional references through reviewing submissions (to the National Institute of Clinical Excellence) by manufacturers, by checking the bibliographies of retrieved articles, and by searching conference proceedings and the Internet. Studies reported in English, German, Dutch and French were eligible for inclusion in the report, but the search strategy had no language restrictions.
منابع مشابه
Effectiveness of trastuzumab as adjuvant therapy in patients with early stage breast cancer: A systematic review and meta-analysis
Background: Trastuzumab in combination with chemotherapy has long been established as a standard treatment for HER2-positive patients in early stage breast cancer (BC). The present study aimed at assessing the effectiveness of trastuzumab adjuvant therapy in early stage BC in overall survival (OS) and disease-free survival (DFS). Methods: A systematic review and meta-analysis was ...
متن کاملBone morphogenic protein receptor type 1a (BMPR1A) and Caveolin-1 associated with trastuzumab resistance of breast cancer cells
Trastuzumab is a specific monoclonal antibody used for therapeutic of the human epidermal growth factor receptor 2 (HER-2) -positive metastatic breast cancer. But, resistance to trastuzumab is a major obstacle in clinical efficiency. During the past years, several studies have been done to find the mechanisms contributing to trastuzumab resistance. Previous studies have highlighted that bone m...
متن کاملComparing the Effectiveness of Digital and Analog Mammography in Breast Cancer Diagnosis and Screening: A Systematic Review and Meta-Analysis
Background & Objectives: Breast cancer is the most common cancer among women and one of the leading causes of death in the productivity ages. Mammography screening is the main method for the diagnosis of breast cancer. While analog mammography counts as the standard method of screening, the digital one can be an alternative. This review compared the effectiveness and safety of these technologie...
متن کاملSubtypes of Benign Breast Disease as a Risk Factor for Breast Cancer: A Systematic Review and Meta-Analysis Protocol
AbstractBreast cancer is a multifactorial disease. Benign breast disease (BBD) is one of the most important risk factors for breast cancer. The etiology of BBD is unknown. It is divided into nonproliferative and proliferative diseases. The selection of studies will be based on titles, abstract screening, inclusion and exclusion criteria, and quality assessment. Previous studies have shown that ...
متن کاملSubtypes of Benign Breast Disease as a Risk Factor of Breast Cancer: A Systematic Review and Meta Analyses
Background: Researchers suggest that benign breast disease (BBD) is a key risk factor for breast cancer. The present study aimed to determinate the risk level of breast cancer in terms of various BBD subgroups.Methods: A meta-analysis was performed to determinate the risk of breast cancer associated with BBD. Observational studies (traditional case-control studies, nested case-control studies, ...
متن کاملResistance to HER2-targeted therapy
Production and approval of trastuzumab (Herceptin®) for the treatment of metastatic breast cancer (MBC) was a millstone in antibody-based targeted therapy in the cancer treatment. However, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. The majority of patients who benefit from the drug...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Health technology assessment
دوره 6 13 شماره
صفحات -
تاریخ انتشار 2002